![]() ![]() ![]() CDC does not currently offer information on every prion disease listed below. ai1(Eq 7.1) In this formula the Greek symbol stands for summation. Listed below are the prion diseases identified to date. Vectors and matrices provide a convenient shorthand for expressions used in the. Prion diseases are usually rapidly progressive and always fatal. The abnormal folding of the prion proteins leads to brain damage and the characteristic signs and symptoms of the disease. The functions of these normal prion proteins are still not completely understood. The term “prions” refers to abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins called prion proteins that are found most abundantly in the brain. The causative agents of TSEs are believed to be prions. They are distinguished by long incubation periods, characteristic spongiform changes associated with neuronal loss, and a failure to induce inflammatory response. Prion diseases or transmissible spongiform encephalopathies (TSEs) are a family of rare progressive neurodegenerative disorders that affect both humans and animals.
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